Dermatological manifestations of Down’s syndrome

In 1866, John Langdon Haydon Down described the characteristic clinical features of this syndrome. In 1959, a chromosomal abnormality was first proven to be responsible for this condition. Since that time, Down’s syndrome has been the subject of many studies. Beside the mental retardation and characteristic physical features, Down’s syndrome has certain dermatological manifestations such as atopic dermatitis, alopecia areata, elastosis perforans, syringoma and frequent skin infections. The frequency of particular skin conditions shows an age-related occurrence. The most common skin manifestations in individuals with Down’s syndrome are presented.