Steroid-induced diabetic ketoacidosis in a 9-year-old boy with relapsing steroid-sensitive nephrotic syndrome

Systemically administered corticosteroids remain the backbone therapy for nephrotic syndrome up to now. Although 80%-90% of children show remission following steroid treatment and are classifi ed as steroid-sensitive nephrotic syndrome, 90% of initial responders will experience relapse at least once, and about 50%-60% may progress to frequent relapsing nephrotic syndrome and hence become steroid dependent. Hyperglycaemia is one of the best-known side eff ects, although most cases are mild and clinically asymptomatic. Presentation with severe hyperglycaemia is possible but rather uncommon. This paper reports a case of steroid-induced diabetic ketoacidosis in a 9-year-old Asian boy with relapsing steroid-sensitive nephrotic syndrome.

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