Biomarkers of allergy in children hypersensitive to Dactilis glomerata allergen during cocksfoot pollination season

The aim was to compare the values of allergy biomarkers, total IgE (uIgE), specific IgE (sIgE) and  specific IgE index (IsIgE) against the cocksfoot (Dactilis glomerata, Dac g) grass allergen and eosinophilic granulocytes in and beyond  the pollination season. Children with confirmed hypersensitivity to cocksfoot allergens (N=80) were  selected and divided into two groups. Group 1 included children examined during the pollination  season (n=64) and group 2 children examined out of the pollination season (n=16). The concentra-  tion of selected parameters was determined by standardized laboratory procedures. The values of all  allergy biomarkers tested, espe- cially sIgE and IsIgE, were statistically significantly higher in  the group of children tested during the cocksfoot flowering season as compared with the group  tested out of the season (p<0.05). Consequently, correlation of the biomarkers was higher during  the season of exposure to the causative allergen. In conclusion, the results obtained indicate that  biomarkers of allergies, sIgE and IsIgE in particular, should be determined at the time of exposure  to the Dac g allergen.
Keywords: ALLERGY AND IMMUNOLOGY; BIOMARKERS; IMMUNOGLOBULIN E
Category: Original scientific paper
Volume: Vol. 65, No 1, january - march 2021
Authors: Anica Džajić, Giorgije Petković, Mateja Šegović
Reference work: Paediatr Croat. 2021;65:1-6
DOI: http://dx.doi.org/10.13112/PC.2021.1

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