Birth weight of iranian children with phenylketonuria

To assess whether birth weight is affected in Iranian patients with phenylketonuria, birth weights of 118 patients with phenylketonuria were compared with 264 healthy controls matched by gestational age and sex, and with patients unaffected siblings. The mean (±SD) birth weight of phenylketonuria patients and control group was 3199.5 (±554.5) and 3260.3 (±483.2) grams, respectively. The mean birth weight of phenylketonuria patients was by 60.7 lower as compared with controls (p=0.27). There was no significant correlation between disease severity and phenylketonuria patient birth weight (p=0.55). The mean (±SD) birth weight of 59 phenylketonuria patients and their siblings was 3193.2 (±568.6) and 3083.9 (±514.0)g, respectively. The mean birth weight of phenylketonuria patients was by 109 g greater as compared with their siblings (p=0.271). Birth weight of Iranian phenylketonuria patients was not significantly lower as compared with their healthy siblings and normal population. Although control infants had a slightly greater birth weight than phenylketonuria infants and phenylketonuria infants had a slightly greater birth weight than their unaffected siblings, the difference was not statistically significant. Furthermore, birth weight was not affected by the disease severity.

Keywords: PHENYLKETONURIAS; BIRTH WEIGHT; IRAN
Category: Original scientific paper
Volume: Vol. 56, No 4, october - december 2012
Authors: F. Rohani, M. Alaei, GA. Totonchi, E. Azargashb
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