Eosinophilia in children with atopic eczema/dermatitis syndrome

Atopic eczema/dermatitis syndrome (AEDS) is a chronic inflammatory skin disease, already manifested in infancy with major and minor features. The aim was to investigate whether there is a difference between the number of eosinophil granulocytes in children with allergic atopic eczema/dermatitis syndrome (AAEDS) and non-allergic atopic eczema/dermatitis syndrome (NAAEDS), and to find the possible correlation between eosinophilia and the severity index of AEDS. The results have shown that the number of eosinophil granulocites was the highest in children with AAEDS with associated asthma and rhinitis (M = 705 x 106/L; IQR = 490 – 1030 x 106/L), and the lowest in children with NAAEDS (M = 290 x 106/L; IQR = 200 – 460 x 106/L). There was a correlation between eosinophils and the severity index in children with NAAEDS and in children with AAEDS without associated allergic respiratory diseases. This retrospective study has shown that eosinophilia was typical for both, children with AAEDS and those with NAAEDS, respectively, and that the degree of eosinophilia was dependent on disease activity.

Category: Original scientific paper
Volume: Vol. 54, No 2, april - june 2010
Authors: S. Dodig, M. Raos, R. Zrinski Topić
Reference work:

Read more