Nasopharyngeal colonisation and resistance of streptococcus pneumoniae, moraxella catarrhalis and haemophilus influenzae in pre-school children with diagnosis otitis media acuta

Nasopharyngeal colonisation with human pathogenic bacteria is a prerequisite for the development of acute otitis media (OAM). Most authors agree that bacterial isolation from nasopharyngeal secretion has clinical signficance. The continuing increase in resistance to commonly used antibiotics makes treatment of these infections difficult in many countries. The purpose of this report was to determine the incidence and resistance in nasopharyngeal isolates in pre-school children with the diagnosis of rhinopharyngitis acuta and otitis media acuta. The objective of this study was to show that usually empiric antibiotic therapy with amoxicillin is not justified. From the total number of nasopharyngeal samples (1229), 468 had a positive bacteriological result (38.08%). Pneumococcus was isolated from 40.60% samples, Moraxella catarrhalis from 40.17%, Haemophilus influenzae from 15.17% samples and from 4.06% samples was isolated BHS-A, C or G. Our results show highly resistance of first isolate - Pneumococcus on penicillin and amoxicillin (37.37%). Empiric therapy of a particular infection with a particular antibiotic is possible only if the antibiotic resistance to the common cause is under 15% in a particular population. The conclusion of this paper is that there is no reason for using penicillin and amoxicillin in empiric therapy for specified infections in our region.
Category: Original scientific paper
Volume: Vol. 52, No 2, april - june 2008
Authors: Z. Trischler-Čeke, D. Bandić, M. Planinić
Reference work:

Read more