The influence of perinatal complications on serum levels of alpha 1-antitrypsin in newborns

In a prospective study alpha 1-antitrypsin (_1-AT) was analysed in 150 newborns (40 healthy term newborns and 110 newborns with perinatal complications- 40 preterm newborns, 40 term newborns with complications and 30 postterm newborns). Plasma levels of _1-AT were measured in the first six hours of life in all newborns, and twice more in newborns with perinatal complications.
The levels of _1-AT were determined with the radial diffusion method on Nor-Partigen plates by Behring. Significant differences were found between plasma levels of healthy newborns and preterm newborns with perinatal complications (p<0,0008), term newborns with perinatal complications (p<0,027) and postterm newborns with perinatal complications (p<0,046). The serum values of _1-AT were significantly lower in healthy newborns.
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Category: Original scientific paper
Volume: Vol. 50, No 3, july - september 2006
Authors: S. Brkić, F. Skokić, N. Mladina, S. Nuhbegović, F. Ljuca
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